Discover single cell molecular immunology
As an immunologist you apply sophisticated methods to enrich rare cells (memory B or T cells, NK cells, cancer cells) via their immunophenotype. Now you would like to learn more about how those cells differ from each other genetically - but conventional methods often are not sensitive enough to deliver consistent result at a reasonable cost per data point.
Now the Advalytix product group of Beckman Coulter has developed a simple, affordable and reliable solution to uncover the genetics of immunology – one cell at a time.
OUR SOLUTION
Many of our customers are immunology researchers; they have helped us to constantly refine and improve our workflows and applications to suit the needs of the immunology community:
• Simple and cost effective integration with flow cytometry
• Open, cost effective single cell workflow
• Protocols for typical immunology applications, such as Ig sequencing, or multiplex rtPCR or qPCR on lymphocytes, respectively
• A community of immunology users to share experiences such as Colette Cywes at the Channing Institute, Rob Barrington at the University of Southern Alabama, or Tom Rothstein at the Feinstein Institute
USER STORIES
- Nichol Holodick, Dr. Thomas Rothstein and colleagues use AmpliGrid to amplify single flow cytometry sorted B-cells followed by InG sequencing.
- Dr. Rob Barrington differentiates sub-groups of extremely rare mouse memory B cells cells using the AmpliGrid system.
- Dr. Collette Cywes uses AmpliGrid to study single cells in a throat infection model.
- Norman Häfner and Matthias Dürst reliably detect single viral copies in single cells in a background of 1.000 non-infected cells.
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